Sofia Vergara

The hilarious Modern Family bombshell from Colombia was only 28 and a mom to a young son, as well as working as a TV host in Miami, when she was diagnosed with thyroid cancer. She had surgery to remove her thyroid, then treatment with radioactive iodine. “I was lucky that’s all I needed,” she later told WebMD. “That kind of cancer is very quiet, and usually you only realize you have it after it’s already spread.” These days, the star, now 45, keeps up her cancer awareness, Instagramming her mammograms and telling fans, “You have to do it!!!!”